I3A - Instituto de Investigación en Ingeniería de Aragón

Biomedical Engineering
Biomedical Engineering
Biomedical Engineering
Biomedical Engineering
Biomedical Engineering
Info
cerrarRadiotherapy treatment planning system
Biomedical Engineering
Biomedical Engineering
Info
cerrarBone modelling
Biomedical Engineering
Biomedical Engineering

The Biomedical Engineering Division is a clear example of the multidisciplinary approach of the I3A, as it brings together specialists in Biology, Medicine, Physics, Mathematics and Engineering who cooperate to develop technological applications to improve human health and quality of life. Current technologies for patient diagnosis, monitoring, therapy, surgery and solutions to help the disabled involve most fields of engineering. The specific research areas include:

  • Tissue engineering and biomaterials
  • Biological modeling and biomechanics
  • Imaging, signal and biomedical instruments
  • Healthcare and prevention technologies

 

Keywords

Mechanobiology, Biomaterials, tissue engineering, microfluidics, Bioreactors, diagnostic devices, cellular behavior modeling, microstructural behavior of biomaterials, heart electrophisiology, Telemedicine, Biomedical signals automatic coding methods, Biomedichal information transmission protocols, smart sensors, Computer visions algorithms for human detection, tracking and activity recognition, Prostheses design, Mesenchymal Stem Cells, Neurodegenerative diseases therapy, Prion Genetics and Genomics, Adapted human-machine interfaces, Indoor/outdoor location and guidance.


Key Projects

Living tissues are regulated by multi-cellular collectives mediated at cellular level through complex interactions between mechanical and biochemical factors. A further understanding of these...

Living tissues are regulated by multi-cellular collectives mediated at cellular level through complex interactions between mechanical and biochemical factors. A further understanding of these mechanisms could provide new insights in the development of therapies and diagnosis techniques, reducing animal experiments.
M2BE proposes a combined and complementary methodology to advance in the knowledge of how cells interact with each other and with the environment to produce the large-scale organization typical of tissues. I will couple in-silico and in-vitro models for investigating the micro-fabrication of tissues in-vitro using a 3D multicellular environment. By computational cell-based modelling of tissue development, M2BE uses a multiscale and multiphysics approach to investigate various key factors: how environmental conditions (mechanical and biochemical) drives cell behaviour, how individual cell behaviour produces multicellular patterns, how cells respond to the multicellular environment, how cells are able to fabricate new tissues and how cell-matrix interactions affect these processes. In-vitro experiments will be developed to validate numerical models, determine their parameters, improve their hypotheses and help designing new experiments. The in-vitro experiments will be performed in a microfluidic platform capable of controlling biochemical and mechanical conditions in a 3D environment. This research is applied in three applications, where the role of environment conditions is important and the main biological events are cell migration, cell-matrix and cell-cell interactions: bone regeneration, wound healing and angiogenesis.

Is your heart aging well? A systems biology to characterize cardiac aging from the cell to the body surface (ERC Starting Grant): MODELAGE proposes a multi-scale,multi-factorial research that...
Is your heart aging well? A systems biology to characterize cardiac aging from the cell to the body surface (ERC Starting Grant): MODELAGE proposes a multi-scale,multi-factorial research that is expected to make an important step in the characterization of human heart aging at both the population and individual levels.
 
MODELAGE will work on an integrative methodological framework in which in silico modeling will be combined with in vitro cell and tissue analysis and in vivo electrocardiographic evaluation to investigate how cardiac aging manifests at a range of scales, from cell to body surface, and how electrical, structural and autonomic alterations contribute to such manifestations in humans.
 
By investigating the mechanisms underlying inter-individual differences in cardiac dynamics, MODELAGE will set links to arrhythmia susceptibility and will propose novel non-invasive markers to identify high-risk senescent individuals for which preventive anti-arrhythmic treatment
should be considered.
 
IP = Esther Pueyo
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